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A limiting risk factor for detecting any major effects of vascular disease is often pointed out as a very low level of blood Hcy concentration and an already quite high folate level

Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis

Numbness can be either short or long-term, and in severe cases, it can also result in paralysis

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So, we recommend using SL vitamin B12 rather than oral and IM, especially in patients who do not tolerate IM injection and patients who need prolonged vitamin B12 supplementation, such as patients with long-term metformin use and patients with pernicious anemia or with gastro-duodenal resection [51,52,53,54]
