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utilized a whole-genome CRISPR-based knockout screen to identify transmembrane protein 2 (TMEM2), a hyaluronidase that degraded hyaluronan in the extracellular matrix, was capable of modulating ER stress through CD44, ERK, and p38

This process disrupts the electrostatic interactions between histones and DNA, thereby leading to chromatin decondensation and the generation of reticular structures with diameters ranging from 10 to 100 nm [99, 100]

After LT, incidence of graft rejection is significantly lower than after transplantation of other solid organs, such as the kidney or heart

In fact, virulence determinants are uniformly distributed in the N

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