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Cooke JR, Ancoli-Israel S

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A fully human anti-c-Kit monoclonal antibody 2G4 inhibits proliferation and degranulation of human mast cells

2.3 NDDS based on TME TME is a complex ecosystem composed of malignant and non-malignant cells, an extracellular matrix, and various biomolecules ( 2 O 2 ), and reducing molecules (such as glutathione and GSH) ( 2.3.1 pH-responsive NDDS Even when oxygen is plentiful, tumor cells tend to metabolize glucose through glycolysis rather than efficient oxidative phosphorylation