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DEHP has been listed as a potential non-genotoxic carcinogen and has been tested in rodents and two CTA models, yielding varied and inconclusive results, demonstrating primarily positive results in the SHE CTA but producing negative outcomes in the BALB/c 3T3 CTA ( in vitro tests in cell cultures, according to good in vitro practices for the development and implementation of in vitro methods for regulatory use in human safety assessments ( Therefore, to enhance the full utilization of CTA in IATA for NGTxC, we conducted a study on DEHP to understand the reasons for the discrepancies observed in various CTA tests and to identify its mechanism of action as a possible non-genotoxic carcinogen

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Oct 19 2011;31(42):14871-81

In contrast, there was clearly no TOA effect of atpenin A5 in suppressing IAV and DENV infection, indicating that these two viruses are inhibited by the compounds action on metabolism

Striking a balance between effective immune activation and avoiding excessive inflammation remains a long-standing challenge