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The tar phase of cigarette smoke contains long-lived radicals, while the gas phase contains short-lived radicals such as nitric oxide and superoxide

45 A simulation using molecular dynamics showed that RVT is a selective estrogen receptor modulator, and its actual effect is highly dependent on the cellular environment and whether co-regulatory proteins are present

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doi: 10.1038/ncomms11190

Deficiency of iPLA2 results in reduced docosahexaenoic acid (DHA) levels, elevated pro-inflammatory factors, and decreased levels of neuroprotective BDNF, thereby triggering microglial activation and inflammatory responses