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An Official Journal of the American Association of Pharmaceutical Scientists, 17 (6), 13831392

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In activated macrophage cultures, GHK-Cu administration reduces the production of pro-inflammatory cytokines including interleukin-1, tumor necrosis factor-, and interleukin-6 by 40-65% while simultaneously increasing the production of anti-inflammatory mediators such as interleukin-10 and transforming growth factor-

Consistently, this inhibition is sufficient for growth arrest and tumor cell killing under conditions of glucose limitation in glioblastoma cells (186)