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Description
Quick recognition helps prevent dangerous progression

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The concept initially consisted of using a lateral margin proportional to the largest tumor diameter, for tumors below 4 cm, and a fixed margin of 4 cm for tumors above this diameter, maintaining a deep margin of at least one fascial plane [150]

It affects the skin, joints, and blood vessel walls

Local injection site reactions were uncommon in the Phase 2 trial, occurring at a lower frequency than systemic gastrointestinal events
