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PMID: 32618595

The other predisposing causes are stagnant urine in the bladder from obstruction from BPH or weak bladder (hypotonic bladder)

Therefore, the commensal microbiota is often regarded as a hidden organ. Commensal microbiota-derived metabolites have substantial impacts on host physiological functions through metabolic reprograming (64), epigenetic modifications (65), and the activation of specific receptors like G protein-coupled receptors (GPRs) and aryl hydrocarbon receptor (AhR)

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Siegel RC, Pinnell SR, Martin GR

A detailed account of how riboflavin is processed in micro-organisms and animals and the production and breakdown of flavoenzymes in both prokaryotic and eukaryotic species can be found in the review by McCormick [50]