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Further, N-Homocysteinylation of both non-histone and histone residues (by increased Hcy thiolactone) represents a post-translational modification [32] that causes also alterations in gene expression [33]

Moreover, complex polymer synthesis and considerable batchtobatch variability pose significant obstacles to clinical translation and largescale manufacturing [28, 29]
Meta-analysis of the association between vitamin D and autoimmune thyroid disease

Using the quantitative methylation-specific PCR (qMS-PCR) analysis, the authors revealed that DNA methylation levels of this gene-based panel were significantly increased in stool samples from CRC patients compared to those with advanced adenoma, non-advanced adenoma, hyperplastic or other polyps, and no-disease patients (SE: 84.8%

The presented model appears to be supported by multiple experimental data (as referenced above)
