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Acupuncture improved hepatic steatosis in HFD-induced NAFLD rats by regulating intestinal microbiota

GHK-Cu was placed in Category 1, though notably not for injectable administration, limiting its use to topical applications for skin health and hair growth

doi:10.1016/j.pnpbp.2008.05.001 pmid:18541357 Pardridge WM, Kang YS, Buciak JL (1994) Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery

In response to stressful conditions, it trimerizes, translocates into the nucleus, binds to the heat shock element of target genes and activates the transcription of HSPs, including HSP70/90 (Noble and Shen, 2012)

Dihexa (full name: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is technically a peptidomimetica small molecule designed to mimic peptide binding activity while having improved stability and bioavailability compared to peptides