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10 Researchers have documented: Reduced ATP production Elevated oxidative stress markers Abnormal lactate responses with exertion Impaired fatty acid oxidation Inflammatory cytokines directly disrupt mitochondrial respiration and increase reactive oxygen species

Incalza MA, DOria R, Natalicchio A, Perrini S, Laviola L, Giorgino F

Environmental Health Perspectives, 114 (12), 18471852

If NMN becomes NAD+ more directly than NR, why bother with NR at all

However, in individuals with low baseline T3 or marginal deiodinase activitysuch as carriers of the DIO2 Thr92Ala polymorphismthis adaptation may lead to fatigue, cold intolerance, or cognitive fog despite normal lab values