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It occurs due to silencing or severe reduction of transcription of the FXN gene, encoding a mitochondrial protein which belongs to the FRATAXIN family, caused by the expansion of GAA trinucleotide repeats within its first intron

Collectively, these findings have provided significant insights into the understanding of the mechanisms underpinning ROS and RNS function in plants, revealing that the ROS/RNS pathway in plant PCD is highly complex and is mediated at least in part by crosstalk with several phytohormone signaling networks

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Available from: /pmc/articles/PMC5465813/ 58

Its primary mechanism involves iron-dependent lipid peroxidation and ROS accumulation (Jiang et al., 2021), accompanied by GSH depletion, thereby impairing normal cellular function