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He pointed to CDC data that showed even healthy children younger than 5, with no underlying conditions, ended up hospitalized with COVID-19 last year

265 Additionally, activation of the Wnt/-catenin signaling pathway has been shown to inhibit IL-1-induced apoptosis of intestinal epithelial cells, increase the expression of ZO-1 and Occludin, improve the structure and function of the intestinal barrier, and reduce inflammatory cell infiltration

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In addition, real-world use is frequently confounded by co-administration of multiple agents and inconsistent sourcing, limiting external validity and complicating attribution of benefit or harm