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10.1111/jgh.16257 165 YouY.LiuC.LiuT.TianM.WuN.YuZ.et al (2022)

Male mice underwent rapid loss of survival at extended time points, while female mice were largely unaffected

Quantitative analysis of GLU, GLY, glutamine, and taurine in tissues was performed according to the following procedure

A 2024 study comparing myocardial tissue from healthy individuals and diabetic heart failure patients demonstrated significantly elevated levels of 4-HNE and its protein adducts in diabetic hearts, suggesting that the diabetic milieu exacerbates myocardial lipid peroxidation injury (Toyokuni et al., 2000)

Also, the VPA has been shown to aggravate folate deficit by blocking critical enzymes in the metabolic pathway of folate during embryogenesis, causing teratogenicity