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10.1093/cercor/7.6.476 [DOI] [PubMed] [Google Scholar] 46.Volk DW, Pierri JN, Fritschy JM, Auh S, Sampson AR, Lewis DA

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2527 In a meta-analysis of studies including the West of Scotland Coronary Prevention Study (WOSCOPS), Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT), and Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) primary prevention trials, the relative risk reduction for those at high genetic risk was 46%, compared with 26% in all other participants ( P for heterogeneity = 0.05)

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The accumulation of misfolded or unfolded proteins leads to ER stress and the activation of the unfolded protein response (UPR), which mainly relies on three transmembrane ER stress sensors, inositol-requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK) and activating transcription factor (ATF6), to restore homeostasis [40]