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Covariates Covariates included age, sex, educational level (as total year of formal education), obtained from structured interviews conducted at the beginning of the study, as well as metabolomic assessment shipment (first vs second)

Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

Moreover, caffeine also prevents alcohol-induced changes in PC and Lyso-PC which activate PPAR/ in addition to other signaling pathways [103], and have been suggested as potential targets for cocaine addiction [104]

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Besides adipokines and cytokines, adipocyte-derived molecules, such as lactate [65] and glutamine [66], function as signaling mediators to facilitate the interaction between adipocytes and ATMs [67]