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Description
As the roles of the insulin-GH-IGF-axis in growth and metabolism, often discussed separately, are intimately linked they will be described jointly here
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In contrast to the inhibition of glutaminolysis, pharmacological or genetic targeting of GLUL in macrophages reprograms M2-polarized macrophages to an M1-polarized phenotype 143
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It modulates over 4,000 human genes, upregulating collagen (COL1A1) and elastin while downregulating pro-inflammatory cytokines like TGF-1 and IL-6
