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In the motor cortex of ALS patients, glutathione (GSH) levels were reported to be reduced when compared to healthy controls 57

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Beyond their antioxidant function, GPx enzymes are involved in various biological processes, including post-translational protein modifications and cellular signaling [8]

68 Considering an apoptotic event, GSH efflux seems to be a logical and important mechanism to avoid the regular protective role of GSH, ensuring that the programmed cell death proceeds as intended