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This high expression of GSTs mediates cellular resistance to antitumor drugs via distinct mechanisms, which mainly involve metabolic detoxification, regulation of the MAPK signaling pathway, DNA repair, autophagy, and glycolytic processes

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At the 2 AR and the CXCR4, detailed mapping of intracellular phosphorylation sites by mass spectrometry defined distinct sites for phosphorylation by individual GRKs, which were associated with distinct functions of -arrestins [95, 96]
These cytoskeletal structures provide the tensile strength that supports tight junctions and maintains cell shape

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