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They have been used safely in research studies lasting as long as 6 years

45% of this volume is cellular part and 55% noncellular part, of which 90% of the noncellular part is plasma, and so the volume of plasma in the central compartment is approximately greater than 3 L

10.1111/aor.14864 14 BernardG

While GHSR1a activity in the hypothalamus is likely heavily involved in homeostatic mechanisms, its presence in extra hypothalamic regions, including a number of limbic and midbrain structures like the ventral tegmental area (VTA), suggest that this receptor is associated in processes associated with learning and motivation (Abizaid et al., 2006

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