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Kroner et al (49) demonstrated that elevated iron levels in microglia promote phagocytosis and drive a harmful M1 phenotype, which triggers the release of pro-inflammatory factors such as TNF-, IL-1, IL-6 and nitric oxide (NO), causing neuronal damage

Therefore, the development of non-invasive or minimally invasive diagnostic procedures, along with the identification of novel biomarkers, is crucial to minimize discomfort and significantly improve the early diagnosis of GC

The primary plasma metabolites are quercetin-3-sulfate and quercetin-3-glucuronide, which reach peak levels at 0.8 h and 0.6 h, respectively (Tomou et al., 2023)

Response rates in the clinical trial were not 100%, and some individuals simply do not show meaningful fat mobilization from this pathway

Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries