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Attention is paid primarily to the attenuation of various intracellular signals in target cells, e.g., rearrangement and disruption of the internalization of the allergen-bridged high-affinity IgE receptor (FcRI), transinhibition or internalization of the FcRI receptor with engagement of the low-affinity inhibitory receptor for the Fc region of immunoglobulin gamma (FcRIIb), synthesis of blocking drug-specific immunoglobulins G4 (IgG4), alteration of signaling pathways in mast cells and/or basophils, and reduced calcium ion (Ca2+) influx into cells (Figure 6) [109,112,113,114]

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Repeated measures ANOVA will be used to examine the change in serum vitamin B12 concentration in each group at each monitoring point

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