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Preclinical evidence base The peer-reviewed literature for the three peptides is uneven

doi: 10.1146/annurev.cellbio.23.090506.123337 77

Reducing mtDNA release The pathological release of mtDNA into the cytosol or extracellular spaceoften due to mitochondrial membrane permeabilization or dysfunctionis the initiating event driving mtDNA-induced inflammation

NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport
