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Also like capsules, the principal challenge to the successful absorption of peptides by nasal spray through the nasal or lung mucosa is the limited bioavailability

Complexation of clarithromycin with -CD increased the solubility of the drug by 700 fold at pH 7.4 [229]

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It's also why benzyl alcohol concentration matters a vial that has been contaminated, frozen incorrectly, or stored too long may have degraded benzyl alcohol distribution, reducing its protective effect even if the water looks clear

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