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Description
Furthermore, intestinal flora dysfunction is a causative agent of CRC by following mechanisms: 1) Flora with its infiltrating metabolites (including secondary bile acids, H2S and NOCs) promotes inflammation, which influences initiation, promotion and progression of carcinogenesis
It is naturally produced in the liver and plays a vital role in detoxifying the body, boosting the immune system, and neutralising free radicals
Dysregulated expression of astrocytic functional proteins, such as glutamate transporter-1 (GLT-1), aquaporin-4 (AQP4), and glutamine synthetase (GS), not only exacerbates mood disorders but also influences seizure thresholds ( activates the Mitogen-Activated Protein Kinase (MAPK) pathway to enhance serotonin transporter (SERT) activity, leading to decreased synaptic 5-HT concentrations and thereby further inducing depressive-like behaviors (Zhu et al., 2010)
doi: 10.1007/s10529-011-0592-x
2018 Feb 1 [cited
