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The BAX/Bcl2 ratio increased 8-fold

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In recent years, click-chemistry has been applied exponentially in the field of PROTAC, since the Huisgen copper-catalyzed alkyne azide cycloaddition (CuAAC) click reaction allows a variety of new triazole compounds to be obtained in a simple, rapid and high-yield manner 167

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These investigations require an interdisciplinary approach, integrating knowledge and methodologies from chemistry, materials science, biology, and clinical medicine

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