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However, systemic administration is hindered by poor blood-brain barrier (BBB) permeability, dose-limiting toxicity, and poor patient compliance due to frequent dosing regimens

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doi: 10.1016/j.rvsc.2022.09.014 85 ZhangH.ChenY.ChenY.LiY.JiaP.JiS.et al
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Bioinformatics 27, 43143210.1093/bioinformatics/btq675 78 SofoA.ScopaA.NuzzaciM.VittiA

Last night, it happen again but BP at 150/100
