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doi: 10.1016/j.jgar.2019.10.005 374 SunGQZhangZCLWangWJLanLHLLuLLFYanYHZet al

This transient, noise-induced paradoxical phenomenon, which precedes the eventual silencing of auditory nerve fibers and synapses, may be characterized by (1) excessive glutamate release from IHCs, resulting in overactivation of receptors on auditory nerve fibers 66 , and (2) functional compensation by LOC efferent neurons, ensuring that auditory nerve activity is enhanced during periods of increased demand 67 , consistent with evidence suggesting that a primary function of LOC efferents is to reduce auditory neuropathy 68

In isolated rat hearts, MAK-4 supplementation improved recovery of cardiac tension after hydrogen peroxide exposure, whereas control hearts exhibited contractile dysfunction throughout the 90-min testing period ( Studies in WHHL rabbits demonstrated that MAK-4 delayed LDL oxidation induced by copper and endothelial cells