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Their constant presence in water bodies may lead to development and acquisition of resistance against the DAs

StAR, steroidogenic acute regulatory protein, and CYP11A1, cytochrome P450 family 11 subfamily A member 1, are markers for Leydig cells, while 3-HSD, 3-beta-hydroxysteroid dehydrogenase, is a key enzyme in testosterone synthesis

Switching to dual-compound therapy (GLP-Squared) makes sense if genetic testing or clinical response suggests multi-pathway engagement is needed

Nature (2020) 585:1026

An intake of 2.4 micrograms a day is recommended for women and men, although this figure can change from one person to another