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An example of such a local production is the recruitment of methionine adenosyltransferase isoform type 2 (MAT2A)

Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1)
J Biol Chem 293, 1197111983 (2018)

Okubo, A

BC has historically been classified into three primary subtypes based on receptor and protein expression: hormone receptor-positive (HR + , approximately 70%), HER2-positive (HER2 + , approximately 20%), and triple-negative (approximately 10%)
