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10.1007/s12264-018-0269-8 22 WangY.LomakinA.KanaiS.AlexR.BelliS.DonzelliM.et al (2016)

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It is under investigation in preclinical and clinical studies on overweight, obesity, and metabolic disorders, where researchers have examined its effects on body weight and energy intake, including when combined with GLP 1 receptor agonists such as semaglutide, but it is not an approved therapy

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These symptoms happen due to nerve damage caused by the deficiency

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