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Acromegaly, a condition characterized by long-standing excess GH secretion, is associated with increased risk of colorectal and thyroid cancers

On the other hand, it has been shown that sulforaphane can counteract oxidative stress and suppress inflammation by decreasing NF-kB leves [207]

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A phase 1 clinical trial aiming to investigate the safety and tolerability of intraputaminal infusion of CDNF in patients with advanced PD and motor fluctuations (NCT03295786, NCT03775538) is recently completed and a long-term follow-up, safety study (NCT04228653) is ongoing until March 2023
