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We also summarize available clinical studies on the role of TMAO in predicting prognostic outcomes, including major adverse cardiovascular events (MACE), in patients presenting with AS

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Treatment with AR antagonist flutamide increased H 2 O 2 levels by approximately 2.4-fold and decreased MMP and ATP production in hepatocytes (120), which further demonstrates the important role of androgens/AR in regulating cellular oxidative stress levels