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In steroidogenic tissues, such as the placenta, ovaries, testes, and adrenal cortex, it is used to hydroxylate intermediates in the conversion of cholesterol to steroid hormones, a process that makes these hydrophobic compounds more water soluble

Furthermore, not everyone with high-risk APOL1 variants develops kidney disease

Specifically, excessive iron accumulation and subsequent induction of ferroptosis can trigger lipid peroxidation in neuronal membranes leading to alterations in their physical and chemical properties

Patients who transition from gastric banding to other bariatric procedures such as sleeve gastrectomy or Roux-en-Y gastric bypass should be aware that these carry a higher risk of B12 and other micronutrient deficiencies due to their malabsorptive components, and monitoring should be intensified accordingly

Although there are multiple theories to explain the mechanism(s) of radiosensitization by cisplatin, two plausible explanations are that cisplatin inhibits the repair (both homologous and nonhomologous) of radiation-induced DNA double-strand breaks and/or increases the number of lethal radiation-induced double-strand breaks