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Treatment of HeLa tumor-bearing mice with cRGD-AuPNS (10 mg/kg) and light irradiation (635 nm, 0.8W/cm 2 ) for 5 min resulted in 100% tumor inhibition rate

This may be due to its antioxidant activity, as well as its ability to regulate several proteins, which are involved in the cell cycle, such as NF- B, STAT3, MAPK, PI3K and a host of others

Another phase II study of CERE-120 showed no significant difference between the treated and control groups (Table 2) (NCT00400634) [83]

Histone associated proteins may prove themselves to be targets for novel pharmaceuticals