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Insulin sensitivity pilot study (Ruggenenti): A pilot study in nondiabetic subjects at increased cardiovascular risk with insulin resistance found that 2 g/day of oral ALCAR for 6 months improved insulin-mediated glucose disposal (measured by euglycemic hyperinsulinemic clamp) alongside reductions in blood pressure [5][21]

Symptoms of FM were previously attributed to dysfunction in central nociceptive sensory processing [15], which was explained by altered pain perception in FM patients, generalized hypersensitivity to unpleasant stimuli, altered cognitive functions, and sleep disturbances [16]

Paul HS, Liu WQ, Adibi SA

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Study inclusion criteria consisted of normal clinical laboratory values, non-pregnant females, lack of chronic disease and medical clearance by physical examination by the study physician