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The progressive degeneration or dysfunction of RPE cells, which is a hallmark of multiple retinal disorders, invariably causes vision loss or even permanent blindness due to the absence of regenerative capacity (80) ( Table 1 )

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Serum insulin was measured using a mouse insulin ELISA kit (#SEKM-0141, Solarbio, Beijing, China), and insulin resistance was calculated using a homeostasis model assessment-2 (HOMA2) index via an online calculator on the Diabetes Trials Unit of the University of Oxford website ( (accessed on 6 April 2024)