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Description
A large portion of the NAD dose eventually reaches circulation, albeit more slowly than IV
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PMID: 17081971
However, systemically reducing p16 Ink4 a or p53-p21 Cip1/Waf1 expression is likely to increase cancer risk since p53 , p21 Cip1/Waf1 , and p16 Ink4a global KO mice have a high prevalence of cancer and hence a shorter lifespan than control mice (250-253)
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