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The acetaldehyde surge has already passed, and the inflammatory cascade (elevated IL-6, TNF-alpha) driving headache and nausea cannot be reversed by post-facto antioxidant supplementation

J Pediatr 143:224230

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High-dose oral supplementation may be another treatment option, because consuming 1,000 g (1 mg) per day of vitamin B 12 orally should result in the absorption of about 10 g/day (1% of dose) by passive diffusion