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The CRISPR/Cas therapy targeting the C9orf72 gene was found to reduce the transcription or levels of repetitive RNA, RNA aggregation and peptide repeat protein production in two studies targeting G4C2 repeat-expanded DNA or RNA, respectively (50, 51)

Other findings implicate alterations in signaling molecules related to synaptic homeostasis, myelin-associated processes and intracellular stress-response pathways
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In addition, inhibition of NMDA receptor function may contribute to some of alcohols behavioral effects

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