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Research findings on glucose homeostasis [6] : Oral glucose tolerance testing showed no negative impact on glucose levels in human subjects No insulin sensitivity changes following chronic exposure Fat-reducing effects occur without inducing insulin resistance Avoids common metabolic complications associated with hGH therapy This metabolic selectivity positions the peptide as targeting adipose tissue lipid metabolism without broader endocrine disruption affecting growth, glucose regulation, or protein synthesis

Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship