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PARSELLS, EDWIN R

Kaplan AM, Vigna SR

An exclusive license for commercial development of these amino acid substitutions enabled argenx to build on the pioneering work by Ward and create a novel Ab-based molecule by removing the Fab arms of the full-length IgG1 used in the proof-of-concept studies [115, 119,120,121]

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They note that weight management is generally more challenging in people with both obesity and type 2 diabetes than in those without diabetes, which makes the results in REDEFINE 2 particularly noteworthy