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Structure 14:225235 Anand A, Luthra A, Edmond ME, Ledoyt M, Caimano MJ, Radolf JD (2013) The major outer sheath protein (Msp) of Treponema denticola has a bipartite domain architecture and exists as periplasmic and outer membrane-spanning conformers

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They discovered that depleting the iSPNs of TrkB signalling leads to increased striatal dopamine due to an increase in the number of dopaminergic cells in the midbrain dopaminergic areas switching from a low dopamine-producing state to a high dopamine-producing state, resulting in striatal neuron vulnerability and motor dysfunction