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For the therapy given continuously from day 14 onward, starting after the established ratio deterioration, the deterioration halted within one week, as assessed on day 21, and the ratio then remained constant, and did not deteriorate until the end of the experiment (i.e., day 30) (Figure 1 and Figure 2)

13 Inflammation mediated by immune cells was enhanced in degenerated IVDs, and degradation products of these cells, such as IL-4, IL-6, IL-12, IFN-, and MMPs, led to a reduction in NP cell number and deterioration of the IVD microenvironment

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