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The phosphorylation of CFTR by PKA is catalyzed by the subunit PKA-cat and regulated by the subunit PRKAR2A through the villin-2 protein (also known as Ezrin) who anchors PKA-cat

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Due to its similar ionic radius and charge, Pb 2+ can compete with or replace Ca 2+ at critical regulatory sites [20], disrupting intracellular calcium homeostasis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 275.Coelho T., Adams D., Silva A., Lozeron P., Hawkins P.N., Mant T., Perez J., Chiesa J., Warrington S., Tranter E
