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Much controversy has arisen around overexpression in nematodes and Drosophila, but few attempts have been made to further characterize the tissue-specific roles and define activities of sirtuins in these genetic systems by manipulationfor example, 20 years after the initial studies, no tissue-specific role for nematodes SIR-2.1 has been reported to date

Are tissue-specific vulnerabilities, similar to the example of erythroid-specific ALAS and its unique vulnerability to translational repression by activated apo-IRP, at play

[DOI] [PubMed] [Google Scholar] [121].Witkowski A, Joshi AK, Smith S

Maubon J, Scanlan M, Thurmond S, Rouanet P

82 The promising mechanism of action of TLK286 and its positive preclinical data have sparked a series of clinical trials where the prodrugs have been applied alone or in combination with other standard chemotherapeutic agents