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The t 1/2 of 6-MAM is longer than that of heroin, although estimates vary greatly from study to study (352 min), and can be detected in the plasma for hours, at a time when heroin has already disappeared [24, 25, 46, 47]

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Cellular heterogeneity in MRD and their relationship to tumor recurrence MRD is characterized by the persistence of heterogeneous tumor cell populations that collectively drive tumor recurrence through distinct yet interconnected biological mechanisms

Adults demonstrate wide physique variability requiring individualized needle size selection

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