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Other conditions that have been associated with MetS are strongly related with insulin resistance and adiposity, namely, non-alcoholic fatty liver disease (NAFLD), polycystic ovarian syndrome, obstructive sleep apnoea (OSA), hypogonadism, lipodystrophy, and microvascular disease

Beyond this, we think that our work has therapeutic implications for more complex organisms

In the SURMOUNT-2 trial for adults with type 2 diabetes, tirzepatide 15 mg produced 14.7% mean weight loss at 72 weeks

Like semaglutide, tirzepatide enhances insulin sensitivity and suppresses appetitebut adds the GIP pathway for potentially even more profound effects

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