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Also, PRMT5 knockdown impairs the self-renewal ability of GBM cells and promotes apoptosis

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(e) Any portion of the amount approved by the corporation for payment to the governor of a State or Territory shall, at his request, and with the approval of the corporation, be paid to any municipality or political subdivision of such State or Territory if (1) the governor makes to such municipality or political subdivision a like certificate as provided in subsection (c) as to the State or Territory, and (2) such municipality or political subdivision enters into an agreement with the corporation for the repayment to the corporation of the amount so paid, with interest at the rate of 3 per centum per annum, at such times, and upon such other terms and conditions, as may be agreed upon between the corporation and such municipality or political subdivision

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Structurally, coumarins can be described as benzene molecules in which two adjacent hydrogen atoms are replaced by a lactone-like chain, forming a second six-membered heterocyclic ring fused with the benzene ring