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Conclusions In this systematic review, evidence revealed that both acute and chronic l-C supplementation could have positive effects on high-intensity (80% O 2 max ) performance exercise outcomes

In the previous studies it was reported that scratching behavior resulted from increase epidermal NO level by nNOS after administration of substance P [30]

Acknowledgements The authors would like to express their sincere gratitude to Department of Biology, College of Science, Salahaddin University-Erbil, Kurdistan Region, Iraq, for their continuous scientific support throughout the course of this study

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We can excavate the value and significance of diabetic wound healing through a comprehensive and systematic study